VirtualBox: supR3HardenedMainGetTrustedMain: dlopen("/opt/VirtualBox/VirtualBox.so",) failed: VBoxVMM.so: cannot open shared object file: No such file or directory

The GNU C library dynamic linker will dlopen arbitrary DSOs during setuid loads

The fix breaks VirtualBox?

To fix this fix, use chrpath to change the runtime load path of *.so